Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex.

TitleBioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex.
Publication TypeJournal Article
Year of Publication2016
AuthorsKJ Yu, D Kuzum, S-W Hwang, BH Kim, H Juul, NH Kim, SM Won, K Chiang, M Trumpis, AG Richardson, H Cheng, H Fang, M Thomson, H Bink, D Talos, KJ Seo, HN Lee, S-K Kang, J-H Kim, JY Lee, Y Huang, FE Jensen, MA Dichter, TH Lucas, J Viventi, B Litt, and JA Rogers
JournalNature Materials
Volume15
Start Page782
Issue7
Pagination782 - 791
Date Published07/2016
Abstract

Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.

DOI10.1038/nmat4624
Short TitleNature Materials