A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain.

TitleA Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain.
Publication TypeJournal Article
Year of Publication2018
AuthorsJE Kleinbart, AL Orsborn, JS Choi, C Wang, S Qiao, J Viventi, and B Pesaran
JournalConference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference
Volume2018
Start Page3362
Pagination3362 - 3365
Date Published07/2018
Abstract

Neural circuitry can be investigated and manipulated using a variety of techniques, including electrical and optical recording and stimulation. At present, most neural interfaces are designed to accommodate a single mode of neural recording and/or manipulation, which limits the amount of data that can be extracted from a single population of neurons. To overcome these technical limitations, we developed a chronic, multi-scale, multi-modal chamber-based neural implant for use in non-human primates that accommodates electrophysiological recording and stimulation, optical manipulation, and wide-field imaging. We present key design features of the system and mechanical validation. We also present sample data from two non-human primate subjects to validate the efficacy of the design in vivo.

DOI10.1109/embc.2018.8512993
Short TitleConference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference