Flexible electronic/optoelectronic microsystems with scalable designs for chronic biointegration.

TitleFlexible electronic/optoelectronic microsystems with scalable designs for chronic biointegration.
Publication TypeJournal Article
Year of Publication2019
AuthorsE Song, C-H Chiang, R Li, X Jin, J Zhao, M Hill, Y Xia, L Li, Y Huang, SM Won, KJ Yu, X Sheng, H Fang, MA Alam, Y Huang, J Viventi, J-K Chang, and JA Rogers
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue31
Start Page15398
Pagination15398 - 15406
Date Published07/2019
Abstract

Flexible biocompatible electronic systems that leverage key materials and manufacturing techniques associated with the consumer electronics industry have potential for broad applications in biomedicine and biological research. This study reports scalable approaches to technologies of this type, where thin microscale device components integrate onto flexible polymer substrates in interconnected arrays to provide multimodal, high performance operational capabilities as intimately coupled biointerfaces. Specificially, the material options and engineering schemes summarized here serve as foundations for diverse, heterogeneously integrated systems. Scaled examples incorporate >32,000 silicon microdie and inorganic microscale light-emitting diodes derived from wafer sources distributed at variable pitch spacings and fill factors across large areas on polymer films, at full organ-scale dimensions such as human brain, over ∼150 cm2 In vitro studies and accelerated testing in simulated biofluids, together with theoretical simulations of underlying processes, yield quantitative insights into the key materials aspects. The results suggest an ability of these systems to operate in a biologically safe, stable fashion with projected lifetimes of several decades without leakage currents or reductions in performance. The versatility of these combined concepts suggests applicability to many classes of biointegrated semiconductor devices.

DOI10.1073/pnas.1907697116
Short TitleProceedings of the National Academy of Sciences of the United States of America